Contemporary Microscale Separation Technology

Chao Yan

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June 2013
342 pp.

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ISBN: 978-0-9828874-2-4



In recent years, microscale separation technology has attracted extensive research interest and has proved to be a powerful analytical tool for a variety of fields. It has the advantages of high separation efficiency, high resolution, and high selectivity with fast speed. Solvent and sample consumption is usually 10,000 times lower than with HPLC, making it economically attractive and environmentally friendly. Since 2006, I have taught a graduate course on contemporary pharmaceutical analysis at Shanghai Jiao Tong University, and capillary electrokinetic separation methods are major topics in the course. I have long thought about a book dedicated to most of the capillary-based liquid separation technologies.

Although microscale separation techniques have been intensively and extensively reported in the literature and at dedicated conferences, there have been only a few books dedicated to the broader scope of microscale separation and analysis. For the purposes of application development and popularization, this book presents, reviews, and summarizes systematically the advances in contemporary microscale chromatographic and electrokinetic separation techniques, including capillary electrophoresis (CE), capillary electrochromtography (CEC), pressurized CEC (pCEC), micellar electrokinetic chromatography (MEKC), capillary isoelectric focusing (CIEF), capillary gel electrophoresis (CGE), capillary isotachophoresis (CITP), and capillary liquid chromatography (CLC), as well as microchip-based LC and multidimensional capillary separations. The book covers the fundamentals, instrumentation, and applications of these techniques to facilitate a systematic understanding for readers.

In spite of the many advances in microseparation techniques, there remain many technical difficulties and associated problems that need to be further studied and solved. Still, microscale analysis offers exciting opportunities for elucidating the mysteries of the separation world. I believe this book will be helpful to professional chemists and graduate students who either face challenging problems in developing new methods or need to improve existing analytical methods with complex samples in the pharmaceutical, biological, environmental, and chemical fields.

I would like to acknowledge many people for their support and assistance, especially Dr. Junhua Wang and Prof. Lingjun Li at the University of Wisconsin--Madison for their contributions to Chapter 4. I also thank my assistants, Dr. Yan Wang and Dr. Xue Gu, for their industrious efforts. I express my thanks to my postdoctoral fellow, Dr. Qishu Qu, and many graduate students, including Juan Wei, Yunyun Xue, Qi Wu, Yuhong Wang, Xiaohui Zhang, Huiping Zhang, Maer Jiang, and Chaoran Wang for their diligent work in helping to write this book. I would also like to thank Henry Boehm for his professional guidance and efforts in the whole process of writing, editing, and publishing this book.

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